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REFLECTIONS
Hypertension
Hypertension Special Edition – ESH 2024 Highlights

Single-pill combination antihypertensive therapy in hypertensive, obese patients:

A prospective, epidemiological study in Romania.
Hypertension
Vintila AM, et al. J. Hypertens. 2024;42(Suppl 1):e38.

Description automatically generatedThis prospective, observational, multicentre study, involving 85 cardiologists and 107 general
practitioners from Romania examined 1299 obese, hypertensive patients to assess BP management with single-pill combination
(SPC) antihypertensive therapy. The most frequently prescribed double SPC at study inclusion were perindopril/indapamide
(81.68%) and olmesartan/amlodipine (5%). Over a three-month period, SBP, DBP, and HR all decreased significantly in both SPC
groups (p<0.001). This study also highlighted that investigators
underestimated the proportion of patients at very high CV risk
(27%) compared to guideline calculated scores using SCORE2 CLICK HERE
and SCORE2-OP (69%). FOR THE FULL ABSTRACT

Achieved systolic blood pressure below 130 mmHg preserves kidney function in
high-risk hypertensive patients without cardiac hypertrophy but with proteinuria.

Olsen E, et al. J. Hypertens. 2024;42(Suppl 1):e12-13.

Kidney function is preserved by achieving SBP primarily <140 mmHg and possibly <130 mmHg in hypertensive patients. This study
aimed to investigate kidney function when achieving SBP 130–139 and <130 mmHg in high-risk hypertensive patients without cardiac
hypertrophy who participated in a major prospective hypertension outcome trial with four to six years of follow-up. The study looked at
2502 patients without cardiovascular events during the first six months after randomization with roll-over from previous medications to
blinded study drugs and had a minimum of three subsequent BP visits, who had proteinuria at baseline (measured twice). In high-risk
hypertensive patients above 50 years of age, but without cardiac hypertrophy, the authors found that when achieving lower average
systolic BP from ≥140 to 130–139 to <130 mmHg, patients with
proteinuria had markedly less worsening of kidney function and
less end-stage renal disease. Parallel diastolic BP <80 mmHg CLICK HERE
gave optimal renal protection. FOR THE FULL ABSTRACT

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